Mb1-Cre
2022-11-17
B6.C(Cg)-Cd79atm1(cre)Reth/EhobJ
鍝佺郴绶ㄨ櫉锛�GAP1093
鍝佺郴绨＄ū锛�Mb1-Cre
鍝佺郴鐗归粸锛�
Cd79a 鍩哄洜鐨�2铏熷拰3铏熷椤瓙宸茶瀵嗙⒓瀛愬劒(y艒u)鍖栫殑 Cre 閲嶇祫閰舵浛鎻�锛�1铏熷椤瓙鐨�ATG瀵嗙⒓瀛愮己澶�锛屾墍浠ュ収婧愭€� Cd79a 鍩哄洜鍔熻兘鏄己澶辩殑銆� Cre 閲嶇祫閰跺緸鏈€鏃╂湡鐨�B娣嬪反绱拌優鍜�B娣嬪反绱拌優鏁村€嬬櫦(f膩)鑲插拰鍒嗗寲閬庣▼閮芥湁琛ㄩ仈銆� 绱斿悎灏忛紶涔熷彲鐢ㄤ簬鐮旂┒ B 绱拌優缂洪櫡銆�
閬哄偝瀛镐俊鎭細
閬哄偝鑳屾櫙锛�C57BL/6J
鍝佺郴椤炲瀷锛�Targeted
鐩搁棞鍩哄洜锛�Mb1-Cre
椋奸(y菐ng)淇℃伅锛�
閰嶇箒绛栫暐锛�
Heterozygote x Heterozygote
閰嶇箒鐗规€э細
缍寔淇濈ó鏅�锛屽彲浠ヤ娇鐢ㄧ磾鍚堝瓙绻佹畺锛�绱斿悎灏忛紶缂轰箯 B 绱拌優骞朵笖鍏嶇柅鍔熻兘浣庝笅銆�
mb1-cre
鎳夌敤闋樺煙锛�
1銆�B娣嬪反绱拌優鐧�(f膩)鑲插拰鍒嗗寲鐨勭爺绌�
2銆�B娣嬪反绱拌優缂洪櫡鐮旂┒
鍙冭€冩枃鐛�锛�
1銆�2006 Testing gene function early in the B cell lineage in mb1-cre mice. Hobeika E , et al Proc Natl Acad Sci U S A 103(37):13789-94
